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PGT-A Pre Implantation Genetic Tesing for Aneuploidy

Preimplantation Genetic Testing for Aneuploidy (PGT-A)

Chromosomes are genetic structures found in nearly every cell of our bodies. The first cell of an embryo is made up of a set of chromosomes from the sperm and another set from the egg. But if the cell doesn’t have the right number of chromosomes, known as aneuploidy, this can lead to implantation failure, miscarriage or a baby affected with a serious condition.

PGT-A is a technique that allows selection of embryos with normal chromosomes from a group of embryos. After ICSI, a few cells from each embryo are sent to the genetics lab and chromosomes are counted. The embryos with a normal number of chromosomes are selected from the group for transfer.

Embryo selection by conventional imaging techniques is not very selective. Good looking embryos are not always good quality embryos. Abnormal embryos often look just like normal embryos under the microscope. When an abnormal embryo results in pregnancy, miscarriage is possible. To compensate, IVF programs may transfer more than one embryo, risking multiple pregnancies.

Patients who can benefit from PGT-A include those:

  • Couples with a history of recurrent miscarriages;
  • Couples who have had several failed IVF attempts;
  • Couples who have had previous pregnancies affected by numerical chromosomal abnormalities;
  • Men with severe male factor infertility;
  • Women over the age of 35.
  • Risk of multiple pregnancies
  • Risk for sex-linked disease in offspring
  • Plans to use a gestational carrier

An embryo that contains a normal number of chromosomes is a ‘euploid’ embryo. An embryo that carries an abnormal number of chromosomes is ‘aneuploid’.

Age is the best predictor of aneuploidy and a major factor to consider when thinking about aneuploidy. In a woman under age 30, about half of embryos are aneuploid. At age 42, around 80% of embryos are aneuploid.

Most of the aneuploid embryos don’t grow, and are never seen clinically. A few aneuploid embryos continue development and result in clinical problems. Miscarriage occurs in about a fourth of pregnancies – most of these are aneuploid.

About 3 out of 4 of these euploid embryos will implant on average (75%  implantation rate), with high pregnancy rates per transfer.

PGT-A Technique:

The technique of PGT-A requires IVF and growing embryos to the blastocyst stage (day 5 to 7). The embryo is “hatched” in the IVF lab using laser, and a few cells sampled from the outer trophectoderm layer of cells (which later goes on to form the placenta and membranes of a pregnancy). The embryo is then vitrified (an advanced technique of embryo freezing), and stored for later transfer back to the uterus if euploid. The biopsied cell samples are sent to a PGT lab for a count of the chromosomes.

Embryos are stored after sampling, since genetic testing takes about 2 weeks. All embryos do well with the freezing-thawing process, with >97% of embryos surviving vitrification and thaw.

Expectations are that on average about 1/10 eggs produces one chromosomally normal embryo.


Advantages of PGT-A include:

  • Improved selection of embryos most likely to result in healthy pregnancy and live birth
  • Reduce the numbers of embryos transferred
  • Reduction in aneuploidy rates
  • Reduction in miscarriage rate
  • Improved implantation rate
  • Reduced multiple (twin or more) pregnancy risk
  • Reduced cryo preservation rates

Disadvantages of PGT-A include:

  • Rare errors in test results, assumed to be mostly due to mosaicism (mixture of euploid and aneuploid cells in an embryo) that is not detected
  • Data on safety incomplete, but reassuring
  • Data on delivered child outcomes is under continued study.

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What Our Client Say

We love that our patients feel inspired to write about the care they received here at Vishvas Fertility! Here are some of the wonderful letters and comments we have recently received.

pramod kr
pramod kr
We visited Dr. Basavaraj for our treatment. We had to visit for over an year and couple of procedures. Doctor is very knowledgeable and has vast experience. Nurses and other lab staff are good. Initially the wait time was less ,however off kate the wait time is on higher side since doctor does scan and procedures in parallel. The wait time doesn't change even with prior appointment . This is especially true in Marathahalli centre. This can be improved. I feel cost here for treatment is much lesser than any corporate hospitals or other centres. Doctor is mostly straight forward and not verbose. Also doctor prescribes just enough medication which might or might not be good, hard to judge.
Rajeev Kothamachu
Rajeev Kothamachu
I highly recommend the doctor if there any complications. I visited him and we got very good results. He has very good patience and listen all the problems. Doc is not that commercial he is collecting the same from last 4 years. We are now visiting him again for 2nd pregnancy..
Divya Sharma
Divya Sharma
Dr Basavaraj is amazing and genuine person. Report asked by him are only needed one, no additional like many other place. All clinic staff are even good n helpful, Appointment recommended Over all very good Dr for fertility.
Vinay K
Vinay K
Very good doctor , provides good information about the procedures ,
Abhijit Sarkar
Abhijit Sarkar
We worship God and many says that Doctors are possibly the one. We (me and my wife) evident that in our difficult time. Thank you Dr. Basavraj for your treatment and care. You will always be there in our heart and any word of gratitude is not enough. We have blessed with a baby boy and he is doing great. we were struggling from almost 3 years and finally we have been blessed. We (me and my wife) can never forgot what you did for us. When in difficult time people goes away, you have been our hope and belief. we were really very lucky enough that we got a chance to meet you in person and got the treatment. Our Best wishes to you Doctor and may you help many more people who are suffering from fertility issues. We were really amazed that even after such a busy schedule doctor finds the time to respond whenever it was required (in panic situations). Thank you once again doctor for your personal attention. Our best wishes for you and your family. We will surely come and meet you very soon, I am sure my son also will be blessed by just seeing you. You have given us the reason to Smile 🙂
Bharath Konegadde
Bharath Konegadde
Dr Basavaraj Shetty take care and advice till 3 months pregnancy . One of the best doctor in hsr
Dr Chetan Kumar N.G
Dr Chetan Kumar N.G
Dr Devarshetty has a midas touch in his treatment apart from his knowledge skills as a infertility specialist. I recommend all patients to be open minded while consulting him. My wife had a very difficult phase in conceiving after getting ectopic pregnancy twice in 2015-16 because of her PCOD . Being a Dr myself i couldn't cope up with the stress with which i and my wife underwent during those times,later in 2016-17 after Dr Devarshetty advise and treatment we finally became parents and it was the most joyous moment of our married life. Now we have a healthy baby girl 10m old..posted mother and baby image.

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